The duration of Zofran’s effects in the body depends on factors such as dosage, individual metabolism, and potential interactions with other medications. Generally, a single dose of Zofran can provide relief from nausea and vomiting for up to 12 hours. However, the specific duration of its effectiveness may vary from person to person. Proper dosing and monitoring by a healthcare professional are essential to optimize Zofran’s efficacy and minimize potential risks.