Pain relievers and antacids play distinct roles in managing pain and indigestion. Pain relievers like Tylenol contain acetaminophen, which reduces fever and aches. Antacids like Tums contain calcium carbonate, which neutralizes stomach acid, relieving discomfort. Both medications can be taken together or separately. There is no interaction between acetaminophen and calcium carbonate, so they can be consumed at different times. Antacids are best taken after meals or when experiencing stomach upset, while pain relievers can be taken with or without food. Follow dosage instructions and consult healthcare professionals for advice.