Mayo is a surname of Irish origin, derived from the Gaelic “Mac Eoin,” meaning “son of John.” It is a common surname in Ireland, Scotland, and other parts of the English-speaking world. The Mayo Clinic, a world-renowned medical center, was founded by a family of physicians named Mayo in the late 19th century. The name “Mayo” has become synonymous with excellence in healthcare, representing the legacy of the founding family and the institution they created.